Creamy Cajun Chicken Spaghetti

This dish is a rich, creamy spaghetti tossed with tender Cajun-seasoned chicken, all coated in a luscious garlic mozzarella sauce. It’s indulgent comfort food with a spicy kick.

Why You’ll Love This Recipe

I love how the sauce melds cream cheese, mozzarella, and Parmesan for maximum creaminess. The Cajun-seasoned chicken adds bold flavor, while spaghetti makes it easy and comforting. I can whip this up quickly for a satisfying weeknight meal or company dinner.

Ingredients

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

• 1 lb boneless, skinless chicken breasts, cut into bite‑sized pieces

• 2 Tbsp olive oil

• 1 lb spaghetti

• 4 Tbsp butter

• 3 cups whole milk

• 1 cup chicken broth

• 8 oz cream cheese, softened

• 2 cups shredded mozzarella cheese, divided

• ½ cup grated Parmesan cheese

Directions

1. Season chicken pieces with Cajun seasoning.

2. Heat olive oil in a skillet over medium-high and cook chicken until browned and cooked through.

3. In a separate pot, cook spaghetti until al dente; drain and set aside.

4. In the same skillet, melt butter. Add milk, chicken broth, and softened cream cheese. Stir until smooth.

5. Add 1 cup mozzarella and the Parmesan, and stir until melted and creamy.

6. Return chicken to skillet, then toss in spaghetti. Stir in remaining 1 cup mozzarella until everything is coated in sauce.

7. Season to taste with salt, pepper, and optional extra Cajun seasoning. Serve immediately.

Servings And Timing

This recipe yields 4 servings and takes about 40 minutes total (including prep and cooking time).

Variations

• Swap chicken for shrimp or smoked sausage for a different flavor profile.

• Use creole seasoning instead of Cajun for milder spice.

• Stir in diced bell peppers, onions, or tomatoes for added texture and color.

Storage/Reheating

• Storage: I keep leftovers in an airtight container in the fridge for up to 3–4 days.

• Reheating: I reheat gently in a skillet with a splash of milk or broth, or microwave in short bursts, stirring in between and adding extra liquid if needed.

FAQs

1. Can I substitute another protein for the chicken?

Absolutely. I sometimes use shrimp, sausage, or even tofu. I just adjust cooking times accordingly.

2. How can I make it less spicy?

I use creole seasoning in place of Cajun, or reduce the amount of Cajun seasoning to suit my taste.

3. Is it okay to freeze the leftovers?

Freezing is not ideal due to the creamy sauce—it might separate. I prefer to refrigerate and enjoy within a few days.

4. What kind of pasta works best?

Spaghetti is classic, but fettuccine, linguine, or penne all work beautifully and hold the sauce well.

5. Can I make it ahead of time?

I recommend serving it fresh, but leftovers reheat well. I store them in the fridge and gently reheat with extra milk or broth to revive the sauce.

Conclusion

This Creamy Cajun Chicken Spaghetti delivers big flavor with minimal fuss. The rich garlic mozzarella sauce and spicy chicken make it a standout meal that comes together in about 40 minutes—perfect for busy nights or casual dinners with friends. I always enjoy the leftovers, too!